Mark Hughes has been relieved of his position as Southampton manager following their poor start to the Premier League.
The Saints have gone 10 matches without victory in the Premier League and lost a two goal lead against United.
The former Stoke City boss leaves with Assistant manager Mark Bowen and assistant coach Eddie Niedzwiecki.
Kelvin Davis, has been given charge of the team temporarily until a new manager is signed. He will hold a news conference on Monday at the club’s training ground before leading them against Tottenham on Wednesday.
“We would like to express our thanks to Mark and his staff for all of their efforts during their time at St Mary’s.
“The search for a new manager to take the club forward is already under way.”
The 55-year-old was initially appointed in March on a temporary basis and was only given a three-year contract in May after securing their Premier League status.