German side, Bayern Munich, recently thrashed Spurs in front of their home crowd.
In a game of nine goals, the Bundesliga champions scored seven, with former Arsenal man, Serge Gnabry, getting four of those.
Spurs had started the brighter of the two sides and got the early goal their efforts deserved through Son Hueng-Min when the South Korean's low drive beat Manuel Neuer 12 minutes into the game.
That lead lasted only three minutes, as Bayern responded in fine fashion. Joshua Kimmich finished off a careful passing move by the Bavarians with an unstoppable drive from 25 yards out after a neat footwork to get past Sissoko.
Niko Kovac's men took the lead on the stroke of half-time when in-form forward, Robert Lewandowski, scored his 13th goal of the season with a delightful effort.
The Polish striker remained alert and swiveled on the edge of the area before powering a crisp low shot into the bottom corner after the Spurs defense switched off.
Bayern resumed the scoring eight minutes after the restart, with Gnabry getting the first of his four goals in the night. The former Arsenal man received the ball from Pavard, zoomed past Aurier down the right flank before beating Alderweireld and smashing a low shot into the net.
Two minutes later, Gnabry was celebrating again. Seemingly shocked by the third goal, Spurs gave the ball away 20 yards out and that created a three on three situation. Tolisso held up nicely before rolling it for Gnabry who clinically fired across Lloris once more to put the German side into an almost unassailable lead.
Harry Kane halved the deficit when he converted from the spot just over the hour-mark after Coman was harshly penalised for his tackle on Danny Rose.
Spurs pushed for another goal to try and rescue something from the game, but that left space behind for the visitors to exploit, which they did.
With seven minutes still left to play, Thiago clipped a delightful lofted pass over Aurier, and Gnabry raced in behind once again before rolling a composed finish beyond Lloris for his first career hat-trick.
On 87 minutes, Lewandowski grabbed his second goal of the game when he shot home another fierce strike before Gnabry put the icing on the cake with a sumptuous finish from 25-yards out.
The defeat was Tottenham's biggest for the North Londoners in the Champions League and the first time they conceded seven at home in any major competition.
Pochettino and his side would need to shake off this embarrasing defeat before their travel to Brighton and Hove Albion in the Premier League on Saturday, while Bayern host Hoffenheim on the same day.