A late Heung-Min Son strike gave Tottenham Hotspur victory against Manchester City in the first leg of their Champions League quarter final tie.
Aguero missed a first half penalty that could have put the Pep Guardiola's men in the drivers seat as Spurs gave themselves a huge fighting chance against one of the competition's favourite.
The London side lost Harry Kane to a nasty injury that would see him miss the return and maybe the rest of the season but Pochettino would be pleased at shutting out one of Europe's best attack.
In their usual manner Manchester City saw more of the ball and played it around nicely but it was Spurs who created the best chances from open play whey they broke in what was Avery cagey game.
The first real chance to open the scoring fell to City after the referee overturned his initial corner kick decision after a VAR review on the touchline.
Sergio Aguero stepped up and placed his short low to Hugo Lloris' left but he guest right and parried away from goal to deny City an early lead. It was the Frenchman's third penalty save in 2019.
Spurs would then grow into the game and create half chances of their own at the other end.
Kane registered the home side's first shot on target with low strike after Eriksen slide a pass to him when the referee played an advantage after Otamendi had taken out Alli on the byline.
From then on both teams kept sizing up each other hoping for a mistake that could lead to an opening. That didn't happen in the first half as both sides went into the break knowing the game was still on the balance.
City created the first chance just two minutes after the restart when Raheem Sterling fired a low shot after receiving the ball from Aguero. Lloris fumbled the tame shot but Alderweireld was on hand to clear.
Son would then fire a warning shot a minute later with a curling left footed shot that was just inches wide of Ederson's right-bottom corner.
And just as the home side was regaining some foothold of the game, tragedy struck. Harry Kane collided with Fabian Delph on the side line and came off worse. The England striker limped straight down the tunnel with Lucas Moura taking his place.
But the mood changed again at the new Tottenham Stadium with 12 minutes left to play. Son gave Spurs the lead against the run of play after drilling a low strike through Ederson after initially miscontrolling Eriksen's delightful pass.
The ball almost gets out of play but he kept it alive, to get round Delph and play a smart finish.
City chased an equaliser, bringing on Leroy Sane and Kelvin De Bruyne for Riyad Mahrez and David Silva, but they couldn't force it as Spurs saw the game off.
Spurs next game is against Huddersfield Town in the Premier League at home on Saturday while City play Crystal Palace on the road on Sunday in their next outing.